Dr. Gavin (Qi) Wang

Gavin

Contact Information
Program in Bioengineering
313 Snell Engineering Center
Northeastern University, Boston, MA 02115
wang.qi1 [at] husky.neu.edu


Degree Objective: Ph.D. Bioengineering
Hometown: Hunan, China
Prior Degrees: B.Sc. Chemistry
Undergraduate Institution: University of Science & Technology of China (USTC)

Biography

Coming soon!

Research

The implanted medical devices provide a surface for bacteria to attach to and grow upon each other resulting in the formation of biofilm. The biofilm structure increases the resistance of bacteria to treatment methods such as antibiotics. Preventing biofilm formation is critical in the fight against healthcare-associated infections (HAIs). In my project, the nanostructured selenium was used to introduce antibacterial properties directly onto the surface of medical devices. Selenium can kill bacteria by depleting their thiol levels. The nano-scale size of selenium nanoparticles increases the surface area available to interact with and kill bacteria, while also changing the surface morphology to ultimately prevent the attachment of bacteria. For this, selenium nanoparticles were synthesized through a simple reaction between glutathione and sodium selenite (4:1 molar mixture) and at the same time were coated on the surface of various medical devices. These substrates included PVC (polyvinyl chloride), polycarbonate, PU (polyurethane), co-polyesters and paper towels. SEM (Scanning Electron Microscopy), AFM (Atomic Force Microscope) and AAS (Atomic Absorption Spectroscopy) were used to determine the distribution, adhesion, surface roughness and the amount of selenium nanoparticles on the surface of substrates. Lastly, experiments with bacteria (specifically, Staphylococcus aureus) were conducted to determine the effectiveness of the selenium coatings for inhibiting bacteria growth and biofilm formation.

Curriculum Vitae

Coming soon!