Kanny (Run) Chang

Ben
 
 
Contact Information
Program in Chemical Engineering
313 Snell Engineering Center
Northeastern University, Boston, MA 02115
chang.r [at] husky.neu.edu
 
 
 


Degree Objective: M.S. Chemical Engineering
Hometown: Guangzhou, China
Prior Degrees: B.Sc. Chemical Engineering
Undergraduate Institution: Zhongkai University of Agriculture & Engineering

Biography

Coming soon!

Research

In my research, the anti-cancer effect of curcumin is evaluated by testing cytotoxicity on MG-63 osteosarcoma cells and human osteoblast cells, and then use Rosette Nanotube (RNT) as an drug-loading material to overcome the low solubility of curcumin in vitro. Curcumin (diferuloylmethane) is an orange-yellow phenolic compound extracted from a natural plant Curcuma longa L. In some previous studies, it has been proven to have significant anti-cancer, anti-oxidant, and anti-inflammation effects. Curcumin has been shown to have inhibitory effect on NF-κB. The activation of NF-κB in tumor cells is relatively higher than normal cells, and is responsible to the development of carcinogenesis. However, curcumin has low bio-avalibility and high degradation rate in the body. On another hand, as RNT has a hydrophilic outter surface that is functionalized by polar functional group, and a hydrophobic inner hollow channel that can encapsulate hydrophobic drug, it is possible to use RNT to deliver curcumin molecules in vitro.

Curriculum Vitae

Coming soon!