Degree Objective: M.Sc. Pharmaceutical Science
Prior Degrees: B.Sc. Marine Pharmacy
Undergraduate Institution: China Pharmaceutical University
Currently, targeting of malignant brain tumors and the delivery of therapeutic agents into the brain remains a big obstacle because of the existence of the blood-brain barrier and the difficulties in finding suitable candidates for specific tumor locating. To address this, superparamagnetic iron oxide nanoparticle (SPIONs) loaded thermosensitive liposomes were developed for better BBB penetration and selective targeting of the brain glioma under mild hyperthermia conditions introduced by an alternating magnetic field (UPT-n2 system, Ultraflex Power Technologies, NY). Based on the drug release results and BBB penetration results, this thermosensitive nanocarrier is suggested to be a good candidate for glioma drug delivery.