Degree Objective: DMD, Ph.D Prosthodontics, Dental Implantology
Titanium (Ti) has been widely used in bone tissue engineering applications for decades (such as for dental and orthopedic applications). Titania (TiO2) forms on the surface of Ti in oxygen containing environments (such as the body) and has been shown to have suitable cytocompatibility properties but no inherent antibacterial properties. Mimicking the same natural hierarchical nano-structured surface features present on the bone on TiO2 may provide natural antibacterial properties to Ti to improve its use in numerous orthopedic applications. TiO2 nanotubes (TNTs) prepared by anodizing Ti under unique conditions have been reported to have great potential in numerous drug delivery applications to fight against bacterial infections. In order to provide extended antibacterial properties to TiO2, which do not involve the use of antibacterial pharmaceutical agents, such as ZnO nanoparticles and Se nanoparticles. Using nanotube incorporated nanoparticles to provide antibacterial properties for TiO2 nanotube. In vitro, using qPCR to find the genetic reason for the observed reduced bacterial growth.